Exploring the intersection of cilia, congenital heart disease, genetics, and developmental biology.

For over 20 years, the Brueckner Lab has explored the overall theme of cilia and cardiogenesis, making impactful findings ranging from basic research to patient studies.

As a physician-scientist, Dr. Martina Brueckner has spent her entire career caring for patients with congenital heart disease (CHD) while elucidating the causal mechanisms through employing genetics, animal models and cell-based approaches in her lab. Our goal as a lab is to advance our understanding of CHD etiology by combining classic developmental cell biology and cutting-edge large-scale genomics with Dr. Brueckner’s continued involvement in clinical pediatric cardiology.


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Interested in our research? We have openings!

We are currently looking for a new post-doc and PhD student. There are openings on all of our projects, and huge flexibility for innovation in these fascinating fields. Join us!

RNF20 protein in an E9.5 mouse heart by Syndi Barish.

Picture Credit: Mouse left-right organizer, calcium was visualized with FLUO4. Overlay is sibling DNAH11 -/- mouse pups, one with situs solitus, one with situs inversus. Picture from Mcgrath et al. (2003).